Is Obesity a Disease of the brain or the body?
Dr.Krishna Prabhakar explains how brain circuits, hormones, genetics, and metabolism interact in obesity—and why modern care (incl. GLP-1s, nutrition, and strength training) works better than “willpower


Why do I regain weight the moment I stop dieting?
I hear this every week. Roughly one in three adults lives with obesity, and many also carry silent risks—pre-diabetes, high blood pressure, fatty liver, and cholesterol problems. The common story is not laziness; it’s a tug-of-war between the brain’s appetite circuits and the body’s energy systems.
The Struggle is real
If any of this feels familar, then you're not alone :
- Persistent cravings despite “eating clean” all week
- Weight cycling after every diet or detox
- Low energy even with 7–8 hours in bed
- Stress eating after long workdays or poor sleep
- Plateaus in spite of daily walks or a gym membership
These are not moral failures; they’re predictable physiology.
The Shift -
The last decade has reshaped care. We now treat obesity like we treat diabetes or hypertension: target the biology first, then layer lifestyle for compounding wins.GLP-1 medications (a class of gut-brain hormones) help the brain feel satisfied sooner, calm reward-driven eating, and steady blood sugar. Paired with protein-forward nutrition, resistance training to protect muscle, and sleep/stress protocols, patients finally see sustainable progress.
The ReverseAll Protocol -
At ReverseAll, medical weight care is not “a prescription and good luck.” We provide:
- Clinician-led evaluation: metabolic labs, medications review, comorbidity screening (T2D, PCOS, NAFLD, hypertension).
- GLP-1 stewardship: eligibility, dosing, side-effect prevention, and discontinuation plans.
- Nutrition & training: a protein-first plate, fiber targets, electrolytes, and strength routines to preserve lean mass.
- Behavioral supports: sleep hygiene, stress tools, and practical craving strategies.
- Follow-ups & data: regular check-ins, outcome tracking, and course-correction.
In my practice, patients on comprehensive care commonly report:
- Clinically meaningful weight loss, with reduced waist circumference (a better marker for visceral fat).
- Improved glucose control (lower fasting sugars and HbA1c in those with insulin resistance or T2D).
- Better blood pressure and lipids, improved fatty liver markers, and higher energy.
- Greater adherence because hunger and cravings are finally manageable.
Every patient is different; outcomes depend on baseline health, adherence, and the care plan.
If you’re exploring GLP-1s or simply exhausted by plateaus, let’s talk. ReverseAll brings medical expertise, nutrition, and coaching under one roof—so your plan fits your biology and your life.
So…Brain or Body?
Both. Obesity is a brain–body condition. The brain sets the appetite and energy “rules,” and the body executes them through hormones, muscle, liver, gut, and fat tissue. Treating one without the other leads to short-term wins and long-term frustration. Treating both—brain signals + body metabolism—is modern, humane, and effective.


